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Organic Letters:程永现小组发现中药干漆或可抗糖尿病肾病

来源:中国科学报 2013-07-22 10:10

据从中科院昆明植物研究所获悉,该所研究员程永现课题组发现,中药干漆具有抗糖尿病肾病活性物质。该研究成果在线发表于《有机化学通讯》。

生漆为漆树科漆树属植物漆树的树脂,有强烈的致敏性。干漆为生漆树脂经加工后的干燥品,其味辛而气温,具有破瘀血、消积和杀虫等功效,用于妇女闭经、瘀血癓瘕等。

程永现表示,他们从该物质中发现的部分新骨架倍半萜类化合物,在高糖诱导的肾系膜细胞株模型上具有显著抑制IV型胶原、纤维连接蛋白和白细胞介素-6过分泌作用,并呈现较好的量效和时效关系。

业内专家表示,由于细胞外基质和促细胞炎性因子过分泌明显发生在糖尿病肾病中,因此,该研究提示,中药干漆及其所含的部分化合物可能具有抗糖尿病肾病的前景。(生物谷 Bioon.com)

生物谷推荐的英文摘要

Organic Letters  DOI: 10.1021/ol4014415

Sesquiterpenoids with New Carbon Skeletons from the Resin of Toxicodendron vernicifluum as New Types of Extracellular Matrix Inhibitors

Jiang-Bo He, Jie Luo, Li Zhang, Yong-Min Yan, and Yong-Xian Cheng

Toxicodenanes A–C (1–3), representing sesquiterpenoids with three new carbon skeletons, were isolated from the dried resin of Toxicodendron vernicifluum. Their structures were identified by spectroscopic data and X-ray diffraction crystallography. Their plausible biosynthetic route was proposed via the isolated intermediate (4). Compounds 2 and 3 could significantly inhibit overproduction of fibronectin, collagen IV, and IL-6 in high-glucose-induced mesangial cells in a dose- and time-dependent manner, showing their potential in diabetic nephropathy.

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