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BMJ Open:维生素C可有效预防运动性支气管痉挛

  1. BMJ Open
  2. 维生素C
  3. 运动性支气管痉挛

来源:生物谷 2013-06-13 21:16

2013年6月13日 讯 /生物谷BIOON/ --近日,刊登在国际杂志BMJ Open上的一篇研究报告中,来自赫尔辛基大学的研究者通过研究表示,维生素C或许可以持续减轻由运动引发的支气管痉挛状况(即运动性支气管痉挛)。 运动性支气管痉挛意味着运动期间或者运动后出现的暂时性气管狭窄现象,其可以引发诸如咳嗽、哮鸣以及呼吸短浅等表现,此前这种疾病表现称为运动性哮喘。

2013年6月13日 讯 /生物谷BIOON/ --近日,刊登在国际杂志BMJ Open上的一篇研究报告中,来自赫尔辛基大学的研究者通过研究表示,维生素C或许可以持续减轻由运动引发的支气管痉挛状况(即运动性支气管痉挛)。

运动性支气管痉挛意味着运动期间或者运动后出现的暂时性气管狭窄现象,其可以引发诸如咳嗽、哮鸣以及呼吸短浅等表现,此前这种疾病表现称为运动性哮喘。通常情况下,运动性支气管痉挛的诊断是由每秒钟的用力呼气量(FEV1)是否低于10%或者更低来进行判断的(运动引发的)。大约10%的人都经历过运动性支气管痉挛,而且在一些冬季运动里其发病率可到50%。

此前研究着发现,维生素C在持久的中短期体力紧张个体中可以降低其一半患普通感冒的比率,这或许可以揭示维生素C对于重体力活动个体的一些其它效应。这篇文章中研究者重点研究了维生素C对运动引发的支气管痉挛的效应,而且研究者在文中还检测了三个相关随机的安慰剂控制组的效应表现。每一组的研究都显示,维生素C可以使得FEV1的降低量减半,维生素C的混合测试显示,其可以使得由运动引发FEV1降低的量减少48%。

最后研究者Hemila总结道,维生素C的廉价和其安全性以及其持续的较好效应,就可以使得我们用维生素C对那些有呼吸道症状如运动相关的咳嗽症状的个体进行测试来验证其效用。(生物谷Bioon.com)

Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis

Harri Hemilä

Objective To determine whether vitamin C administration influences exercise-induced bronchoconstriction (EIB). Design Systematic review and meta-analysis. Methods MEDLINE and Scopus were searched for placebo-controlled trials on vitamin C and EIB. The primary measures of vitamin C effect used in this study were: (1) the arithmetic difference and (2) the relative effect in the postexercise forced expiratory volume in 1 s (FEV1) decline between the vitamin C and placebo periods. The relative effect of vitamin C administration on FEV1 was analysed by using linear modelling for two studies that reported full or partial individual-level data. The arithmetic differences and the relative effects were pooled by the inverse variance method. A secondary measure of the vitamin C effect was the difference in the proportion of participants suffering from EIB on the vitamin C and placebo days. Results 3 placebo-controlled trials that studied the effect of vitamin C on EIB were identified. In all, they had 40 participants. The pooled effect estimate indicated a reduction of 8.4 percentage points (95% CI 4.6 to 12) in the postexercise FEV1 decline when vitamin C was administered before exercise. The pooled relative effect estimate indicated a 48% reduction (95% CI 33% to 64%) in the postexercise FEV1 decline when vitamin C was administered before exercise. One study needed imputations to include it in the meta-analyses, but it also reported that vitamin C decreased the proportion of participants who suffered from EIB by 50 percentage points (95% CI 23 to 68); this comparison did not need data imputations. Conclusions Given the safety and low cost of vitamin C, and the positive findings for vitamin C administration in the three EIB studies, it seems reasonable for physically active people to test vitamin C when they have respiratory symptoms such as cough associated with exercise. Further research on the effects of vitamin C on EIB is warranted.

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