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J Prote Res:婴幼儿食品喂养可增加婴儿成年后代谢疾病的风险

来源:生物谷 2013-06-06 23:47

2013年6月5日 讯 /生物谷BIOON/ --近日,刊登在国际杂志Journal of Proteome Research上的一篇研究报告中,来自国外的研究者通过研究表明,如果用婴幼儿食品喂养婴儿而不是进行母乳喂养,那么婴儿会经历某些代谢性应激反应,婴幼儿食品喂养也与儿童患肥胖、II型糖尿病以及其它成年后疾病有着重要的关联。

在此前研究中,研究者Carolyn Slupsky和其同事揭示了婴幼儿食品喂养与成年后慢性疾病的风险升高有直接关系,当然从科学认知的角度理解这种关系还是存在一定差距的,随后研究者用猕猴进行试验来对比用婴幼儿食品喂养和母乳喂养对婴儿的影响差别。

研究者通过对猴子的尿液、血液以及粪便样品进行分析就能比较其用婴幼儿食品喂养和母乳喂养所引发的差别。研究同样显示,降低婴幼儿食品中的蛋白质成分或许对于降低婴儿代谢性应激反应非常有帮助。

最后研究者表示,我们的研究发现证明了婴幼儿的喂养方式对于其代谢发育有着巨大的影响,喂养的方式或许也是其早期喂养和后期代谢性疾病产生的一个重要关联。(生物谷Bioon.com)

Early Diet Impacts Infant Rhesus Gut Microbiome, Immunity, and Metabolism

Aifric O’Sullivan ‡§, Xuan He ‡, Elizabeth M. S. McNiven ‡, Neill W. Haggarty , Bo Lönnerdal ‡, and Carolyn M. Slupsky *‡§

Epidemiological research has indicated a relationship between infant formula feeding and increased risk of chronic diseases later in life including obesity, type-2 diabetes, and cardiovascular disease. The present study used an infant rhesus monkey model to compare the comprehensive metabolic implications of formula- and breast-feeding practices using NMR spectroscopy to characterize metabolite fingerprints from urine and serum, in combination with anthropometric measurements, fecal microbial profiling, and cytokine measurements. Here we show that formula-fed infants are larger than their breast-fed counterparts and have a different gut microbiome that includes higher levels of bacteria from the Ruminococcus genus and lower levels of bacteria from the Lactobacillus genus. In addition, formula-fed infants have higher serum insulin coupled with higher amino acid levels, while amino acid degradation products were higher in breast-fed infants. Increases in serum and urine galactose and urine galactitol were observed in the second month of life in formula-fed infants, along with higher levels of TNFα, IFN-γ, IL-1β, IL-4, and other cytokines and growth factors at week 4. These results demonstrate that metabolic and gut microbiome development of formula-fed infants is different from breast-fed infants and that the choice of infant feeding may hold future health consequences.

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