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The Open Virol J:特定类型的人类乳头瘤病毒或可抑制宫颈癌的发生

来源:生物谷 2013-04-14 23:28

2013年4月14日 讯 /生物谷BIOON/ --近日,刊登在国际杂志The Open Virology Journal上的一篇研究报告中,来自曼彻斯特大学的科学家通过研究表明,特定类型的乳头瘤病毒或许可以组织宫颈癌的发生。

目前研究发现有100多种不同类型的人类乳头状瘤病毒(HPV),其中有14种所谓的高风险HPV可以引发宫颈癌发生。

这项研究中,研究者对来自肯尼亚HIV阳性和阴性,且患有侵入性宫颈癌的妇女机体中不同类型的HPV进行研究,研究发现,在HIV阳性但宫颈涂片正常的女性机体中发现了较高数量的53型HPV,但是这种类型的HPV在HIV阴性患者中却极为罕见,而且这种类型的病毒在宫颈癌女性(不论其是否HIV阳性)中并没有发现。

研究者Ian Hampson说道,众所周知,在任何一个病人中HIV可以增加不同类型HPV的数量,这就意味着HIV为患者感染HPV开通了一扇大门,如果仅仅是高风险HPV类型的话,那么毫无疑问会加速患者癌症的风险,但是如果是其它HPV类型,如53型,那么实际上其可以和其它高风险HPV病毒竞争,从而来抑制宫颈癌的发生。

研究者的这项研究揭示了,尽管HIV非洲阳性女性中HPV的感染数量在逐渐上升,但是这和其宫颈癌发生率的增加并没有关系。

研究者表示他们目前会对这一领域进行深入研究,研究者Hampson说,我们需要更为深入地研究来揭示特定类型的HPV如何抑制宫颈癌的发生,如果53型的HPV病毒的确可以抑制宫颈癌的发生,这或许可以帮助我们开发出抑制宫颈癌发生的生物靶向疗法,这或许也可以为那些低资源的国家提供一些建议,不必让其承担高额HPV疫苗的费用。(生物谷Bioon.com)

HIV Infection Alters the Spectrum of HPV Subtypes Found in Cervical Smears and Carcinomas from Kenyan Women, 2013; 7: Pp. 19-27

Innocent O. Maranga, Lynne Hampson, Anthony W. Oliver, Xiaotong He, Peter Gichangi, Farzana Rana, Anselmy Opiyo and Ian N. Hampson

Infection with high risk HPV is implicated in pre-cancerous squamous intraepithelial lesions and their progression to cervical cancer. In the developed countries, infection with HPV 16 and 18 accounts for ~70% of cervical cancers, but it has been established that HPV type prevalence differs according to worldwide geographical location. In sub Saharan Africa infection with HPV is known to be augmented by HIV, which is endemic in this region. It is not yet clear, however, whether this ultimately influences progression to cervical cancer. PapillocheckTM and multiplex PCR were used to determine the range of HPV genotypes found in cervical smears and carcinomas from HIV positive and negative Kenyan women. Smear samples from HIV-positive women had a higher prevalence of: multiple HPV infections; high-risk HPVs 52, 58, 68, potential high risk 53/70, low-risk 44/55 and abnormal cytology compared to HIV-negative women. A low overall prevalence (~8%) of types 16/18 was found in all smear samples tested (n = 224) although this increased in invasive cervical carcinoma tissues to ~80% for HIV-negative and ~46% for HIV-positive women. Furthermore, HPV45 was more common in cervical carcinoma tissues from HIV-positive women. In summary HIV infection appears to alter the spectrum of HPV types found in both cervical smears and invasive cervical carcinomas. It is hypothesised there could be a complex interplay between these viruses which could either positively or negatively influence the rate of progression to cervical cancer.

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