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CEBP:起床后越早抽烟个体越易患肺癌和口腔癌

来源:生物谷 2013-04-01 00:12

2013年4月1日 讯 /生物谷BIOON/ --近日,来自宾夕法尼亚州立大学的研究人员通过研究表示,在早上醒来时候越早抽烟的个体,其就越容易患上肺癌或者口腔癌,相关研究成果刊登于国际杂志Cancer,Epidemiology,Biomarkers and Prevention上。

研究者Steven Branstetter表示,我们发现,相比早上起来晚些时候抽烟的个体,那些早上起来之后立刻抽烟的个体血液中存在高水平的NNAL,这是烟草特殊致癌物NNK的一种代谢产物。有研究表明,NNK可以在许多啮齿类动物中诱发肺部肿瘤,血液中高水平的NNAL可以来预测肺癌风险,另外NNAL的水平在吸烟者中一直处于稳定的水平。

在这项研究中,研究者对1945名吸烟的成年个体参与者进行了研究,这些参与者均提供了其抽烟行为的相关信息,包括其早上醒来之后多久开始抽烟等信息。通过分析研究,研究者发现,参与者中有32%的个体在早上醒来之后的5分钟内开始抽烟,31%的个体是在醒来后的6至30分钟内抽烟,18%的个体在醒来后的31分钟至60分钟内抽烟,19%的个体是在醒来后1小时之后抽烟。另外研究者表示,参与者血液中的NNAL水平和参与者开始抽烟的年龄、性别等因素也有关系。

Branstetter说道,更为重要的是,我们发现,早上醒来之后立马抽烟的个体,其体内NNAL的水平是最高的,那么其患口腔癌或者肺癌的风险就是最高的。吸第一支烟的时间或许是判断吸烟者患癌风险的一个重要因素,当然研究者希望开发出某些干预策略来有效干预这些个体,降低其患癌风险。(生物谷Bioon.com)

Time to First Cigarette and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol (NNAL) Levels in Adult Smokers; National Health and Nutrition Examination Survey (NHANES), 2007–2010

Steven A. Branstetter1 and Joshua E. Muscat2

Background: The time to first cigarette (TTFC) is a good indicator of several dimensions of nicotine dependence. An early TTFC is also associated with increased lung and oral cancer risk. Our objective was to determine the relationship between TTFC and exposure to tobacco smoke carcinogens. Methods: We conducted a cross-sectional analysis of a nationally representative subsample of smoking adults that had urinary samples analyzed for tobacco biomarkers. The study included 1,945 participants from the 2007–2008 and 2009–2010 National Health and Nutrition and Examination Survey. The main outcome measure was creatinine-adjusted urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) levels. Results: The cigarette-per-day adjusted levels of NNAL were twice as high in participants who smoked within 5 minutes after waking than in participants who refrained from smoking for at least 1 hour (0.58 vs. 0.28 ng/mL, P < 0.001). In multivariate linear models, a shorter TTFC was significantly associated with increasing NNAL levels, after adjusting for cigarettes smoked per day (or cotinine), secondhand smoke exposure, age, sex, race/ethnicity, and other potential confounders. Conclusions: These data show that in a nationally representative sample, there is a dose-dependent relationship between earlier smoking in the day and higher biologic exposure to a tobacco smoke carcinogen. Impact: Our study provides further evidence that highlights the relationship between TTFC, nicotine dependence, and cancer risk. Cancer Epidemiol Biomarkers Prev; 22(4); 1–8. ©2013 AACR.

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