新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » BIOON报道 » JASN:成纤维细胞生长因子23与肾脏疾病患者心脏健康相关

JASN:成纤维细胞生长因子23与肾脏疾病患者心脏健康相关

来源:生物谷 2013-03-25 21:09

2013年3月21日 讯 /生物谷BIOON/ --根据一项发表在Journal of the American Society of Nephrology杂志的最新研究证实:肾脏对一种特殊的荷尔蒙的响应可能会影响肾脏疾病患者的心脏健康和长寿,这一发现可能有助于医生监测和治疗肾脏疾病患者。

在慢性肾脏病(CKD)患者血液中激素成纤维细胞生长因子23(FGF-23)水平上升,伴随肾功能下降,导致尿液中的磷排泄过量。此外,FGF-23始终与心脏疾病和过早死亡,但这背后的机制目前还不清楚。

Julie Dominguez,MD和他的同事不知道肾脏对荷尔蒙FGF-23的响应是否可能发挥在上述现象中作用。他们测量了872例慢性肾脏病和心血管疾病患者血液中FGF-23和尿中磷的含量。其中的主要结果:在平均7.5年的随访研究中,有337人死亡和199人出现心血管事件,如心脏病发作和中风。

尿中磷的排泄量显著改变了FGF-23与过早死亡和心脏疾病之间的联系。患者有高于平均水平的FGF-23,但低于平均水平尿磷的话,过早死亡和心血管事件的风险最高。

调查结果表明,FGF-23与过早死亡和心血管事件之间的联系在肾功能降低患者中尤为明显。在这些人士中,肾脏对FGF-23的响应可能不是最优的。(生物谷:Bioon.com)

Fibroblast Growth Factor-23 and Outcomes: New Answers, New Questions

Scoville, BA

Fibroblast growth factor-23 (FGF23) induces phosphaturia through its effects on renal tubules. Higher levels of FGF23 associate with cardiovascular disease (CVD) events and all-cause mortality, but it is unknown whether these associations differ by the degree of phosphaturia. Here, we measured serum FGF23 and 24-hour urine fractional excretion of phosphorus (FePi) in 872 outpatients with stable CVD and a mean estimated GFR of 71 ml/min per 1.73 m2. During an average 7.5 years of follow-up, there were 337 deaths and 199 CVD events. Urinary FePi significantly modified the association of FGF23 with each outcome (P interaction<0.001 for all-cause mortality and P interaction<0.05 for CVD events). In models adjusted for CVD risk factors, kidney function, and PTH, those patients who had FGF23 above the median (≥42.3 relative units [RU]/ml) but FePi below the median (<15.7%) had the highest risks of both all-cause mortality (HR=1.98, 95% CI=1.42–2.77) and CVD events (HR=1.92, 95% CI=1.25–2.94) compared with those patients who had low concentrations of FGF23 and low FePi. In summary, associations of FGF23 with mortality and CVD events are stronger in persons with lower FePi independent of PTH and kidney function. In such individuals, the renal tubular response to FGF23 may be suboptimal.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库