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PLoS ONE:高湿度的室内环境或可有效降低流感病毒的感染能力

来源:生物谷 2013-02-28 23:55

2013年2月28日 讯 /生物谷BIOON/ --近日,刊登在国际杂志PLoS ONE上的一篇研究报告中,来自美国国家职业安全与健康研究所、美国疾病控制和预防中心的研究人员通过研究揭示了,室内高的湿度水平可以明显降低由咳嗽所释放的流感病毒颗粒的传染性。

这项研究标题为“High Humidity Leads to Loss of Infectious Influenza Virus from Simulated Coughs.”研究中,研究者通过利用模拟咳嗽感染细胞的实验,检测了相对湿度抑制流感病毒传染性的能力。

通过研究,研究者发现,控制室内湿度为23%或者以下之后一个小时,有70%-77%的病毒颗粒都可以保持自身的传染性,但是当湿度增加至43%时,仅仅有14%的病毒颗粒具有感染细胞的能力。

研究者发现,当将流感病毒颗粒释放到高湿度环境中后,在十五分钟内,大部分的病毒都会失去感染的活性。这项研究揭示了,维持室内40%以上的湿度环境可以明显降低流感病毒的传染能力,这对于公众保持健康的身体状况来说至关重要。(生物谷Bioon.com)

High Humidity Leads to Loss of Infectious Influenza Virus from Simulated Coughs

John D. Noti mail, Francoise M. Blachere, Cynthia M. McMillen, William G. Lindsley, Michael L. Kashon, Denzil R. Slaughter, Donald H. Beezhold

Background The role of relative humidity in the aerosol transmission of influenza was examined in a simulated examination room containing coughing and breathing manikins. Methods Nebulized influenza was coughed into the examination room and Bioaerosol samplers collected size-fractionated aerosols (<1 µM, 1–4 µM, and >4 µM aerodynamic diameters) adjacent to the breathing manikin’s mouth and also at other locations within the room. At constant temperature, the RH was varied from 7–73% and infectivity was assessed by the viral plaque assay. Results Total virus collected for 60 minutes retained 70.6–77.3% infectivity at relative humidity ≤23% but only 14.6–22.2% at relative humidity ≥43%. Analysis of the individual aerosol fractions showed a similar loss in infectivity among the fractions. Time interval analysis showed that most of the loss in infectivity within each aerosol fraction occurred 0–15 minutes after coughing. Thereafter, losses in infectivity continued up to 5 hours after coughing, however, the rate of decline at 45% relative humidity was not statistically different than that at 20% regardless of the aerosol fraction analyzed. Conclusion At low relative humidity, influenza retains maximal infectivity and inactivation of the virus at higher relative humidity occurs rapidly after coughing. Although virus carried on aerosol particles <4 µM have the potential for remaining suspended in air currents longer and traveling further distances than those on larger particles, their rapid inactivation at high humidity tempers this concern. Maintaining indoor relative humidity >40% will significantly reduce the infectivity of aerosolized virus..

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