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Sci Transl Med:肠道微生物或可加重三聚氰胺引发的肾脏疾病

  1. Sci Transl Med
  2. 三聚氰胺
  3. 肠道微生物
  4. 肾结石
  5. 肾脏疾病

来源:生物谷 2013-02-15 23:40

2013年2月15日 讯 /生物谷BIOON/ --近日,来自北卡罗来纳大学等处的研究者通过研究揭示,肠道中本身存在的微生物可以影响由三聚氰胺引发的个体肾脏疾病的严重性。相关研究成果刊登于国际著名杂志Science Translational Medicine上。

2013年2月15日 讯 /生物谷BIOON/ --近日,来自北卡罗来纳大学等处的研究者通过研究揭示,肠道中本身存在的微生物可以影响由三聚氰胺引发的个体肾脏疾病的严重性。相关研究成果刊登于国际著名杂志Science Translational Medicine上。

2008年,将近有30万中国儿童因为服用含有三聚氰胺的牛奶而患肾脏疾病入院,尽管我们都知道,三聚氰胺可以在机体内与尿酸结合产生有害的肾结石,但是具体的反应机理以及儿童肠道中微生物在疾病发病过程中所扮演的角色尚不清楚。

通过在大鼠中研究三聚氰胺如何促成肾结石的形成,研究者们在实验条件下揭示了肠道微生物或许是理解三聚氰胺诱发的肾衰竭的关键因素。

当三聚氰胺和氰尿酸在肾脏中形成不能够在血管中溶解的结晶体之后,就预示着肾结石开始形成了。研究者表示,特定类型的肠道微生物可以将三聚氰胺转化成为有毒的氰尿酸,这就会加速肾结石的形成速度。

在对大鼠的实验结果显示,克雷伯菌属在肠道中的存在会加速三聚氰胺向氰尿酸转化,研究者Nicholson教授表示,肠道微生物的代谢活性可以以很多方式明显地影响人类的机体健康,并且和多种自体免疫疾病直接相关联。当前的研究揭示了,添加三聚氰胺的牛奶对儿童肾脏健康的危害很有可能有一部分原因是肠道微生物所引发的有害作用而导致的。(生物谷Bioon.com)

Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota

Xiaojiao Zheng1,2,*, Aihua Zhao1,2,*,†, Guoxiang Xie3, Yi Chi2, Linjing Zhao2, Houkai Li3, Congrong Wang1, Yuqian Bao1, Weiping Jia1, Mike Luther4, Mingming Su4, Jeremy K. Nicholson5 and Wei Jia1,2,3,†

Melamine poisoning has become widely publicized after a recent occurrence of renal injury in infants and children exposed to melamine-tainted milk in China. This renal damage is believed to result from kidney stones formed from melamine and uric acid or from melamine and its cocrystallizing chemical derivative, cyanuric acid. However, the composition of the stones and the mechanism by which the stones are formed in the renal tubules are unknown. We report that cyanuric acid can be produced in the gut by microbial transformation of melamine and serves as an integral component of the kidney stones responsible for melamine-induced renal toxicity in rats. Melamine-induced toxicity in rats was attenuated, and melamine excretion decreased after antibiotic suppression of gut microbial activity. We further demonstrated that melamine is converted to cyanuric acid in vitro by bacteria cultured from normal rat feces; Klebsiella was subsequently identified in fecal samples by 16S ribosomal DNA sequencing. In culture, Klebsiella terrigena was shown to convert melamine to cyanuric acid directly. Rats colonized by K. terrigena showed exacerbated melamine-induced nephrotoxicity. Cyanuric acid was detected in the kidneys of rats administered melamine alone, and the concentration after Klebsiella colonization was increased. These findings suggest that the observed toxicity of melamine may be conditional on the exact composition and metabolic activities of the gut microbiota.

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