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Cancer Preve Res:高纤维饮食可抑制前列腺癌恶化

来源:生物谷 2013-01-10 22:28

2013年1月10日 讯 /生物谷BIOON/ --近日,刊登在国际杂志Cancer Prevention Research上的一篇研究报告中,来自美国科罗拉多大学癌症中心的研究者通过研究发现,高纤维饮食或具有控制早期前列腺癌患者癌症发展的作用。

前列腺癌在亚洲的发病率与在欧洲基本类似,在众多患者中,前列腺癌都会趋向于恶化的地步,但是对于亚洲地区的患者来说,前列腺癌并不会恶化,其中原因是什么?科罗拉多大学癌症中心表示,有可能是因为高纤维饮食的作用。

在这项研究中,研究者将以肌醇六磷酸喂食的小鼠与不喂食的小鼠进行对照研究,肌醇六磷酸(IP6)是高纤维饮食中的一种重要组分。随后研究者使用MRI技术来监控小鼠模型中的前列腺癌发展情况。

研究者Komal Raina说,这项研究的意义非常深远,通过研究我们发现小鼠模型中前列腺癌体积有明显的缩小,而且这取决于IP6的癌症抗血管生成效应。基本来讲,给小鼠喂食高纤维饮食的活性成分可以有效抑制前列腺癌肿瘤生成新的血管来维持肿瘤自身的能量。没有了充足的能量供应,前列腺癌细胞就不能生长。类似地,使用IP6的相关疗法也可以明显降低前列腺癌进行葡萄糖代谢的比率。

IP6抵御前列腺癌代谢的可能机制包括一种名为GLUT-4蛋白质的减少,这种蛋白质对于运输葡萄糖非常重要。

研究者Raina表示,很长时间以来很多研究者都在亚洲和欧洲人之间寻找基因突变,来解释前列腺癌的恶化比率,但是如今研究看来,引发这种癌症恶化的比率似乎并不是基因突变所引起的,而是由于饮食所引起的,亚洲人可以通过进行高纤维饮食摄取较多的IP6,而欧洲人并没有获得足够的IP6来抵御癌症的发生。(生物谷Bioon.com)

Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study

Komal Raina1, Kameswaran Ravichandran1, Subapriya Rajamanickam1, Kendra M. Huber2, Natalie J. Serkova2,3, and Rajesh Agarwal1,3

Herein, employing anatomical and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), we evaluated noninvasively, the in vivo, chemopreventive efficacy of inositol hexaphosphate (IP6), a major constituent of high-fiber diets, against prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate (TRAMP) model. Male TRAMP mice, beginning at 4 weeks of age, were fed with 1%, 2%, or 4% (w/v) IP6 in drinking water or only drinking water till 28 weeks of age and monitored using MRI over the course of study. Longitudinal assessment of prostate volumes by conventional MRI and tumor vascularity by gadolinium-based DCE-MRI showed a profound reduction in tumor size, partly due to antiangiogenic effects by IP6 treatment. As potential mechanisms of IP6 efficacy, decrease in the expression of glucose transporter GLUT-4 protein together with an increase in levels of phospho-AMP-activated kinase (AMPKTh172) were observed in prostate tissues of mice from IP6 fed-groups, suggesting that IP6 is interfering with the metabolic events occurring in TRAMP prostate. Investigative metabolomics study using quantitative high-resolution 1H-NMR on prostate tissue extracts showed that IP6 significantly decreased glucose metabolism and membrane phospholipid synthesis, in addition to causing an increase in myoinositol levels in the prostate. Together, these findings show that oral IP6 supplement blocks growth and angiogenesis of prostate cancer in the TRAMP model in conjunction with metabolic events involved in tumor sustenance. This results in energy deprivation within the tumor, suggesting a practical and translational potential of IP6 treatment in suppressing growth and progression of prostate cancer in humans. Cancer Prev Res; 6(1); 40–50; ©2012 AACR.

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