新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » BIOON报道 » JAMA:果糖消耗与体重增加之间的关联

JAMA:果糖消耗与体重增加之间的关联

来源:生物谷 2013-01-03 23:19

2013年1月2日讯 /生物谷BIOON/ --在一项研究果糖消费和体重增加之间关联的新研究中,研究参与者大脑磁共振成像后表明葡萄糖而不是果糖的摄入减少脑血流和大脑调节食欲区域的活动,葡萄糖的摄取而不是果糖的生成能增加饱腹感,相关研究发表在1月2日的JAMA上。

耶鲁大学医学院Kathleen A. Page医学博士和同事进行了一项研究探讨神经电生理因素,可能是果糖消费与体重增加之间关联的基础。这项研究包括了20名健康成年志愿者,研究人员对他们进行了两次磁共振成像研究以及分析果糖或葡萄糖饮料的摄入。主要研究指标为葡萄糖或果糖摄入后下丘脑区域局部脑血流量(CBF)相对变化。

研究人员发现,葡萄糖与果糖摄入后下丘脑CBF有一个显著减少。葡萄糖而不是果糖摄入能减少下丘脑、岛叶和纹状体的激活,这些大脑区域与调节食欲,激励和奖赏效应相关,葡萄糖摄取也增加了下丘脑与纹状体之间的功能性连接,增加了饱腹感。(生物谷:Bioon.com)

Effects of Fructose vs Glucose on Regional Cerebral Blood Flow in Brain Regions Involved With Appetite and Reward Pathways.

Kathleen A. Page et al.

Importance  Increases in fructose consumption have paralleled the increasing prevalence of obesity, and high-fructose diets are thought to promote weight gain and insulin resistance. Fructose ingestion produces smaller increases in circulating satiety hormones compared with glucose ingestion, and central administration of fructose provokes feeding in rodents, whereas centrally administered glucose promotes satiety.

Objective  To study neurophysiological factors that might underlie associations between fructose consumption and weight gain.

Design, Setting, and Participants  Twenty healthy adult volunteers underwent 2 magnetic resonance imaging sessions at Yale University in conjunction with fructose or glucose drink ingestion in a blinded, random-order, crossover design.

Main Outcome Measures  Relative changes in hypothalamic regional cerebral blood flow (CBF) after glucose or fructose ingestion. Secondary outcomes included whole-brain analyses to explore regional CBF changes, functional connectivity analysis to investigate correlations between the hypothalamus and other brain region responses, and hormone responses to fructose and glucose ingestion.

Results  There was a significantly greater reduction in hypothalamic CBF after glucose vs fructose ingestion (?5.45 vs 2.84 mL/g per minute, respectively; mean difference, 8.3 mL/g per minute [95% CI of mean difference, 1.87-14.70]; P = .01). Glucose ingestion (compared with baseline) increased functional connectivity between the hypothalamus and the thalamus and striatum. Fructose increased connectivity between the hypothalamus and thalamus but not the striatum. Regional CBF within the hypothalamus, thalamus, insula, anterior cingulate, and striatum (appetite and reward regions) was reduced after glucose ingestion compared with baseline (P < .05 significance threshold, family-wise error [FWE] whole-brain corrected). In contrast, fructose reduced regional CBF in the thalamus, hippocampus, posterior cingulate cortex, fusiform, and visual cortex (P < .05 significance threshold, FWE whole-brain corrected). In whole-brain voxel-level analyses, there were no significant differences between direct comparisons of fructose vs glucose sessions following correction for multiple comparisons. Fructose vs glucose ingestion resulted in lower peak levels of serum glucose (mean difference, 41.0 mg/dL [95% CI, 27.7-54.5]; P < .001), insulin (mean difference, 49.6 μU/mL [95% CI, 38.2-61.1]; P < .001), and glucagon-like polypeptide 1 (mean difference, 2.1 pmol/L [95% CI, 0.9-3.2]; P = .01).

Conclusion and Relevance  In a series of exploratory analyses, consumption of fructose compared with glucose resulted in a distinct pattern of regional CBF and a smaller increase in systemic glucose, insulin, and glucagon-like polypeptide 1 levels.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库