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Diabetes Care:低胰岛素分泌与妇女抑郁症

  1. 抑郁症
  2. 胰岛素

来源:生物谷 2013-04-27 15:20

2012年12月30日讯 /生物谷BIOON/ --相比于具有较高胰岛素分泌水平的中年妇女,胰岛素分泌水平最低的五分位数的中年妇女似乎有两倍以上的风险出现新发抑郁症状,相关研究论据发表在12月10日的Diabetes Care杂志上。

2012年12月30日讯 /生物谷BIOON/ --相比于具有较高胰岛素分泌水平的中年妇女,胰岛素分泌水平最低的五分位数的中年妇女似乎有两倍以上的风险出现新发抑郁症状,相关研究论据发表在12月10日的Diabetes Care杂志上。

伦敦大学学院(University College London)Tasnime N. Akbaraly博士和他的同事进行了一项前瞻性队列研究,涉及3145名成人(23.5%为女性),平均年龄为60.6岁,检查了血糖,胰岛素抵抗,胰岛素分泌随后新发抑郁症状之间的相关性。

研究人员发现,142位男性和84位女性五年后续追访研究中出现抑郁症状。对于胰岛素分泌水平最低的五分位数的中年妇女,新发抑郁症状的几率增高了2.18倍,相对于那些有较高的胰岛素分泌而言。

炎症标志物,皮质醇的分泌或绝经状态、激素替代疗法没有解释两者之间的关联。但需要进一步的工作来证实低胰岛素分泌是否是中年妇女新发抑郁症状的一个危险因素。(生物谷:Bioon.com)

Glycemia, Insulin Resistance, Insulin Secretion, and Risk of Depressive Symptoms in Middle Age

Tasnime N. Akbaraly,et al.

OBJECTIVE The extent to which abnormal glucose metabolism increases the risk of depression remains unclear. In this study, we investigated prospective associations of levels of fasting glucose and fasting insulin and indices of insulin resistance and secretion with subsequent new-onset depressive symptoms (DepS).

RESEARCH DESIGN AND METHODS In this prospective cohort study of 3,145 adults from the Whitehall II Study (23.5% women, age 60.6 ± 5.9 years), baseline examination included fasting glucose and insulin level, the homeostasis model assessment of insulin resistance (HOMA2-%IR), and the homeostasis model assessment of β-cell insulin secretion (HOMA2-%B). DepS (Center for Epidemiologic Studies Depression Scale ≥16 or use of antidepressive drugs) were assessed at baseline and at 5-year follow-up.

RESULTS Over the 5-year follow-up, DepS developed in 142 men and 84 women. Women in the lowest quintile of insulin secretion (HOMA2-%B ≤55.3%) had 2.18 (95% CI 1.25–3.78) times higher odds of developing DepS than those with higher insulin secretion. This association was not accounted for by inflammatory markers, cortisol secretion, or menopausal status and hormone replacement therapy. Fasting insulin measures were not associated with DepS in men, and fasting glucose measures were not associated with new-onset DepS in either sex.

CONCLUSION Low insulin secretion appears to be a risk factor for DepS in middle-aged women, although further work is required to confirm this finding.

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