新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 疫苗 » Am J Epidemiol:疫苗保护婴儿抵抗呼吸道合胞病毒

Am J Epidemiol:疫苗保护婴儿抵抗呼吸道合胞病毒

来源:生物谷 2012-11-25 19:42

2012年11月24日 讯 /生物谷BIOON/ --近日,英国华威大学一项研究表明,接种疫苗的家庭可以保护小宝宝对常见冬季病毒的感染,一些冬季常见病毒对6个月以下的婴儿是致命的。

呼吸道合胞病毒(RSV)通常会导致成人和年龄较大的儿童轻微的,类似感冒的症状,但对年龄六个月以下婴幼儿可能更严重,甚至是致命的,因为它可以导致支气管炎和肺炎。该病毒通常在世界各地都存在。在英国,通常在十一月或十二月和来年的四、五月开始爆发,高峰在圣诞节和新年期间。
 
据健康保护局报道,在英国,28%一岁以下的儿童感染呼吸道合胞病毒。截至目前为止,这未明确是否6个月以下的婴儿更易呼吸道合胞病毒感染,导致严重的呼吸疾病。
 
发表在American Journal of Epidemiology杂志上一项由威康信托基金资助新研究中,证实呼吸道合胞病毒是与年龄有关的疾病。而减少感染风险就是接种疫苗。在婴儿不接种疫苗的情况下,另一种方法是接种疫苗的父母或父辈6个月大的婴儿,因为这一时期是病毒最活跃的时间。一旦周边人接种疫苗后,虽然婴儿没有直接接种,但周围的人就不可能通过传染感染婴儿。(生物谷:Bioon.com)

The Natural History of Respiratory Syncytial Virus in a Birth Cohort: The Influence of Age and Previous Infection on Reinfection and Disease.

E. O. Ohuma, E. A. Okiro, R. Ochola, C. J. Sande, P. A. Cane, G. F. Medley, C. Bottomley, D. J. Nokes.

This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infection and the effect of age and infection history on the risk of respiratory syncytial virus disease. A birth cohort of 635 children in Kilifi, Kenya, was monitored for respiratory syncytial virus infections from January 31, 2002, to April 22, 2005. Predictors of infection were examined by Cox regression and disease risk by binomial regression. A total of 598 respiratory syncytial virus infections were identified (411 primary, 187 repeat), with 409 determined by antigen assay and 189 by antibody alone (using a “most pragmatic” serologic definition). The incidence decreased by 70% following a primary infection (adjusted hazard ratio = 0.30, 95% confidence interval: 0.21, 0.42; P < 0.001) and by 59% following a secondary infection (hazard ratio = 0.41, 95% confidence interval: 0.22, 0.73; P = 0.003), for a period lasting 6 months. Relative to the age group <6 months, all ages exhibited a higher incidence of infection. A lower risk of severe disease following infection was independently associated with increasing age (P < 0.001) but not reinfection. In conclusion, observed respiratory syncytial virus incidence was lowest in the first 6 months of life, immunity to reinfection was partial and short lived, and disease risk was age related. a

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库