新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 免疫学 » Immunity:最近发现的小鼠免疫细胞有助改善疫苗接种

Immunity:最近发现的小鼠免疫细胞有助改善疫苗接种

来源:生物谷 2012-10-25 11:07

2012年10月25日 讯 /生物谷BIOON/ --近日,研究人员发现小鼠免疫细胞的一个子集可以用来开发更好的疫苗接种策略。有关小鼠动物研究为我们全面了解人类疾病作出了不可估量的贡献。然而,这种动物模型是不是没有它的局限性,科学家们正在不断研究小鼠和人类生物学方面的不同。

树突状细胞(DC)是免疫系统的前线,能捕捉病原体的抗原,使得一类免疫细胞细胞毒性T细胞识别病原体。

研究人员Ginhoux解释说:这一过程是非常重要的,DC可提呈肿瘤衍生的抗原或病毒抗原,你想要设计及一个好的疫苗就必须得到一个良好的细胞毒性T细胞反应。

小鼠皮肤内发现的DCs的一个子集,在这个过程中起着一个特别突出的作用,但在人类中同类细胞的作用尚未被确定。DC各类亚群看起来相似,但彼此​​有不同的功能,可以通过表面蛋白来进行区分。经过仔细的分析,Ginhoux和他的同事发现皮肤细胞中高表达的CD141蛋白质能有效地将DC亚群分离和鉴定。(生物谷:Bioon.com)

 

Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells

Haniffa, M., Shin, A., Bigley, V., McGovern, N., Teo, P. et al

Dendritic cell (DC)-mediated cross-presentation of exogenous antigens acquired in the periphery is critical for the initiation of CD8+ T cell responses. Several DC subsets are described in human tissues but migratory cross-presenting DCs have not been isolated, despite their potential importance in immunity to pathogens, vaccines, and tumors and tolerance to self. Here, we identified a CD141hi DC present in human interstitial dermis, liver, and lung that was distinct from the majority of CD1c+ and CD14+ tissue DCs and superior at cross-presenting soluble antigens. Cutaneous CD141hi DCs were closely related to blood CD141+ DCs, and migratory counterparts were found among skin-draining lymph node DCs. Comparative transcriptomic analysis with mouse showed tissue DC subsets to be conserved between species and permitted close alignment of human and mouse DC subsets. These studies inform the rational design of targeted immunotherapies and facilitate translation of mouse functional DC biology to the human setting.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库