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BMJ:适量饮酒与较低风险患上肾癌相关联

  1. 整合分析
  2. 群体研究
  3. 肾癌
  4. 风险
  5. 饮酒

来源:生物谷 2012-11-18 23:31

肾癌可能影响大约1%的总人口。之前的大多数流行病学研究已表明适量饮酒与较低风险患上肾癌相关联。在已经发布的前瞻性群体研究(prospective cohort study)中,在适量饮酒的人们当中患上肾癌的风险通常要比不饮酒的人们降低大约25%。

肾癌可能影响大约1%的总人口。之前的大多数流行病学研究已表明适量饮酒与较低风险患上肾癌相关联。在已经发布的前瞻性群体研究(prospective cohort study)中,在适量饮酒的人们当中患上肾癌的风险通常要比不饮酒的人们降低大约25%。

这项比较好的整合分析支持如下发现:相对于更加可靠的前瞻性群体研究而言,当前发表在British Journal of Cancer 期刊的新研究发现相对于饮酒最少的实验参与者,饮酒最多的参与者患上肾癌的风险下降29%。

这些发现提示着不论是男人还是女人,也不论哪种类型的酒精饮料,都存在类似的影响。

不过需要注意的是,这种影响在参与者每天喝一杯酒的水平上观察到的,喝更多的酒不会导致患肾癌的风险进一步降低。(生物谷:Bioon.com)

本文编译自Moderate alcohol intake is associated with a lower risk of kidney cancer

Alcohol intake and renal cell cancer risk: a meta-analysis

D Y Song, S Song, Y Song and J E Lee

Background: An inverse association between alcoholic beverage intake and risk of renal cell cancer has been suggested in recent studies. Methods: We examined the association between alcoholic beverages and renal cell cancer risk in a meta-analysis. We identified relevant studies by searching the database of PubMed, EMBASE, and MEDLINE published through August 2011. We combined the study-specific relative risks (RRs) using a random-effects model. Results: A total of 20 case–control studies, 3 cohort studies, and 1 pooled analysis of cohort studies were included in the meta-analysis. We observed that alcoholic beverage intake was associated with a lower risk of renal cell cancer in combined analysis of case–control and cohort studies; for total alcoholic beverage intake, combined RRs (95% confidence intervals) comparing top with bottom categories were 0.76 (0.68–0.85) in case–control studies, and 0.71 (0.63–0.78) in cohort studies (P for difference by study design=0.02). The inverse associations were observed for both men and women and for each specific type alcoholic beverage (beer, wine, and liquor). Also, we found that one drink per day of alcoholic beverage conferred the reduction in renal cell cancer risk, but further drinking above that level did not add benefit. Conclusion: The findings from our meta-analysis support the hypothesis that alcoholic beverage intake is inversely associated with a lower risk of renal cell cancer, with moderate consumption conferring the protection and higher consumption conferring no additional benefits.

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