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J Materi Chem:潘浩波等生物活性材料微环境研究获进展

  1. J Materi Chem
  2. 微环境
  3. 潘浩波
  4. 生物活性材料
  5. 进展

来源:深圳先进技术研究院 2012-11-18 11:32

中国科学院深圳先进技术研究院医药所(筹)人体组织与器官退行性研究中心潘浩波副研究员领导的科研攻关小组近期在生物活性材料微环境研究方面取得新进展。相关成果发表在英国皇家化学学会期刊Journal of Materials Chemistry上。 生物材料的降解会在局部营造一个不同于生理条件的微环境,这时材料周边pH值发生显著性变化,研究同时发现碱性微环境对成骨意义重大。

中国科学院深圳先进技术研究院医药所(筹)人体组织与器官退行性研究中心潘浩波副研究员领导的科研攻关小组近期在生物活性材料微环境研究方面取得新进展。相关成果发表在英国皇家化学学会期刊Journal of Materials Chemistry上。

生物材料的降解会在局部营造一个不同于生理条件的微环境,这时材料周边pH值发生显著性变化,研究同时发现碱性微环境对成骨意义重大。而在以往的研究中,人们往往只重视释放离子的效应,却忽略了离子释放后对周边溶液pH的影响,以及pH自身对成骨及破骨的作用。

此项研究强调了材料周边微环境的重要性,对生物活性材料的研发提出了新的思路。(生物谷Bioon.com)

Bone regeneration: importance of local pH—strontium-doped borosilicate scaffold

Yuhui Shen , Waiching Liu , Chunyi Wen , Haobo Pan , Ting Wang , Brian W Darvell , William W Lu and Wenhai Huang

The effect of local pH on bone regeneration has never been properly studied or discussed. However, using a microelectrode, the pH on the surface of implant materials, rather than in the bulk, is measurable so that the biological response based on the local environment can be studied. It was found that the osteoblast viability was significantly enhanced with an increase of pH, to an optimum level at pH 8–8.5; in contrast, the activity fell markedly below pH 6. The effect of strontium on osteoblast proliferation was further increased at pH 8, suggesting a possible new approach for enhancing its activity in the treatment of osteoporosis. No stimulation of osteoblast proliferation was found for boron at normal physiological pH but, surprisingly, such an effect was found at pH 8.5. For the degradation of strontium-doped borosilicate, the ambient alkaline pH not only enhanced the activity of strontium and boron, but also facilitated the nucleation of apatite, as indicated by the newly formed bony tissue. Consequently, appropriately designed biomaterials, which create such an ideal ambient alkaline environment for bone regeneration, may be crucial aspects for bone substitutes.

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