新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 病毒微生物 » Cell Microbiol:广州生物院发现HSV感染激活潜伏EB病毒的重要通路

Cell Microbiol:广州生物院发现HSV感染激活潜伏EB病毒的重要通路

来源:广州生物医药与健康研究院 2012-05-07 19:08

人类疱疹病毒具有长期潜伏感染的特点。潜伏感染的病毒的重新激活会给机体带来严重的危害。EBV是疱疹病毒科γ亚科的病毒,根据流行病学调查及文献报道,全世界90%以上的人都感染过该病毒,并且EBV与多种人类疱疹病毒都存在共感染的现象。作为可以引起鼻咽癌、Burkitt淋巴瘤、T细胞淋巴瘤以及淋巴组织增生等严重疾病的人类疱疹病毒,对于其从潜伏周期到裂解周期的激活机制还不是十分清楚。

中科院广州生物医药与健康研究院彭涛博士课题组近日研究发现,单纯疱疹病毒(Herpes simplex virus,HSV)的超感染可激活潜伏感染的EB病毒(EBV)。该研究首次发现“HSV-PKA-CREB-BZLF1”以及“HSV US3-CREB-BZLF1”是HSV感染激活潜伏EBV的重要信号通路。

研究同时还发现,目前治疗疱疹病毒的方法并不能治疗由共感染引发的EBV的激活。因此,从临床治疗以及预防的角度来看,在预防EBV复发感染时,也应注意预防HSV以及其他人类疱疹病毒的感染。

本研究将为疱疹病毒的治疗和预防提供新的思路。该研究成果于2012年4月在Cellular Microbiology正式发表。(生物谷:Bioon.com)

Herpes simplex virus type 1 infection activates the Epstein–Barr virus replicative cycle via a CREB-dependent mechanism

Hongling Wu1,†, Ting Li1,†, Musheng Zeng2, Tao Peng1,*

The reactivation of latent Epstein–Barr virus (EBV) to lytic replication is important in pathogenesis and requires virus–host cellular interactions. However, the mechanism underlying the reactivation of EBV is not yet fully understood. In the present study, herpes simplex virus type 1 (HSV-1) was shown to induce the reactivation of latent EBV by triggering BZLF1 expression. The BZLF1 promoter (Zp) was not activated by HSV-1 essential glycoprotein-induced membrane fusion. Nevertheless, Zp was activated within 6 h post HSV-1 infection in virus entry-dependent and replication-independent manners. Using a panel of Zp deletion mutants, HSV-1 was shown to promote Zp through a cyclic adenosine monophosphate (cAMP) response element (CRE) located in ZII. The phosphorylated cAMP response element-binding (phos-CREB) protein, the cellular transactivator that binds to CRE, also increased after HSV-1 infection. By transient transfection, cAMP-dependent protein kinase A and HSV-1 US3 protein were found to be capable of activating Zp in CREB- and CRE-dependent manners. The relationship between EBV activation and HSV-1 infection revealed a possible common mechanism that stimulated latent EBV into lytic cycles in vivo.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库