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Front. Evol. Neurosci:过度担心或与智力共同进化

来源:生物谷 2012-04-16 15:17

据最近一项研究报道,担心作为一种有益性状可能与智力一起进化,研究人员发现,高智慧与担心都与大脑活动相关,其中大脑活动通过大脑皮层下白质中营养胆碱的耗竭来衡量。这表明,人类智慧可能与担心共同进化。

然而,过度担心通常被认为是负面性状,高智慧则为正面性状,担心可能会使我们避免某些危险境况,无论这些危险境况是多么遥远。担心本质上可能使人不冒险,于是,担心的人可能有更高的存活率。因而,担心就象智慧一样,可能是赐予物种的一大益处。

在这项焦虑与智慧的研究中,将广泛性焦虑症患者(GAD)与健康志愿者进行比较,以评估智商(IQ)、担心和皮层下白质胆碱代谢间的关系。在正常志愿者对照组中,高智商与低程度担心相关,但是,在那些被诊断为广泛性焦虑症的患者中,高智商则与更大程度担心相关。在GAD组与健康对照组中,智商和担心之间的相关性都很显著。然而,在GAD组中,相关性是积极的,在健康对照组中,则是消极的。研究对象是18名健康志愿者(8名男性,10名女性)和26名GAD患者(12名男性,14名女性)。

以前的相关研究已指出,过度担心往往既在高智力人群中发生,也在低智力人群中发生,较少在中等智力人群中发生。据推测,较低智力的人因为实现的人生成功少而更易发生焦虑。(生物谷bioon.com)

The Relationship between Intelligence and Anxiety: An Association with Subcortical White Matter Metabolism

Jeremy D. Coplan, Sarah Hodulik, Sanjay J. Mathew, Xiangling Mao, Patrick R. Hof, Jack M. Gorman, Dikoma C. Shungu

We have demonstrated in a previous study that a high degree of worry in patients with generalized anxiety disorder (GAD) correlates positively with intelligence and that a low degree of worry in healthy subjects correlates positively with intelligence. We have also shown that both worry and intelligence exhibit an inverse correlation with certain metabolites in the subcortical white matter. Here we re-examine the relationships among generalized anxiety, worry, intelligence, and subcortical white matter metabolism in an extended sample. Results from the original study were combined with results from a second study to create a sample comprised of 26 patients with GAD and 18 healthy volunteers. Subjects were evaluated using the Penn State Worry Questionnaire, the Wechsler Brief intelligence quotient (IQ) assessment, and proton magnetic resonance spectroscopic imaging (1H-MRSI) to measure subcortical white matter metabolism of choline and related compounds (CHO). Patients with GAD exhibited higher IQ's and lower metabolite concentrations of CHO in the subcortical white matter in comparison to healthy volunteers. When data from GAD patients and healthy controls were combined, relatively low CHO predicted both relatively higher IQ and worry scores. Relatively high anxiety in patients with GAD predicted high IQ whereas relatively low anxiety in controls also predicted high IQ. That is, the relationship between anxiety and intelligence was positive in GAD patients but inverse in healthy volunteers. The collective data suggest that both worry and intelligence are characterized by depletion of metabolic substrate in the subcortical white matter and that intelligence may have co-evolved with worry in humans.

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