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The Lancet :林浩添等收集到完整的结膜吸吮线虫病档案

来源:中国科学报 2012-02-27 10:16

近日,国际著名杂志《柳叶刀》The Lancet 在线刊登了中山大学眼科中心研究人员的最新研究成果,研究者林浩添首次收集到完整的结膜吸吮线虫病临床资料,该研究成果并成为该杂志1月在线阅读点击量最大的文章。

据介绍,结膜吸吮线虫于1910年首次被发现,是一种专门寄生于狗、牛等动物眼睛里的寄生虫,也可寄生于人的眼中,由此虫感染的疾病叫结膜吸吮线虫病,是一种罕见的人畜共患疾病。由于该病多发生于亚洲地区,故称为东方眼虫病。人眼寄生了结膜吸吮线虫后,轻者导致眼睛刺痒、有异物感,重者造成眼内感染,甚至失明。

2010年10月,惠州市一名38岁的女性患者,因右眼有虫子蠕动感,到中山眼科中心就诊。接诊的林浩添详细询问其病史后发现,该患者没有任何其他全身或视觉症状,也无其他疾病史,但眼睛出现不适症状前3个月,在她干农活时,曾有昆虫飞进其右眼。

林浩添发现患者右眼鼻侧上睑处的结膜上有虫爬行,经诊断证实了眼睛里有活虫的存在。这些活虫经鉴定为结膜吸吮线虫。经过治疗及半年随诊,患者眼睛里没有发现新的活虫,也没有蠕动感等不适症状。

据了解,虽然结膜吸吮线虫病在我国已有数百例报道,但在正规医学文献中几乎为空白。林浩添发现该病例后,马上拍摄了相关图片,在进行诊治和随访的同时,记录和保留了结膜吸吮线虫病完整的临床资料,包括临床症状、资料过程、图片等。这些详细、完整的临床资料,使《柳叶刀》接受了该研究成果并予以发表。(生物谷Bioon.com)

Eye can see a nest of worms!

Haotian Lin, Dr Xiaoling Liang

In October, 2010, a 38-year-old woman presented with creeping sensation in her right eye, but without any systemic or visual symptoms. Her medical history was notable only for an unknown insect flying into her right eye during farm work about 3 months earlier. On examination, a live worm was seen moving out from the nasal upper eyelid of the right eye above the conjunctiva (figure A). This was further viewed with anterior segment optical coherence tomography (figure B). When proxymetacaine eye-drops were administered, preparing the eye for surgical exploration, more than two worms were seen moving (figure C, D). The worm nest in the superior-nasal subconjunctiva tissue was completely cleared. The worms were all removed and identified as one female and two male Thelazia callipaeda. The creeping sensations resolved immediately, with no recurrence after 6-month follow-up. Thelazia callipaeda infects orbital cavities and associated tissues of man and other carnivores. Drosophila is its vector host, and it tends to infect individuals residing in poor communities in Asia, particularly in China.

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