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Diabetologia:研究发现女性患糖尿病易致婴儿先天缺陷

  1. Diabet
  2. 先天缺陷
  3. 女性
  4. 婴儿
  5. 糖尿病

来源:新华社 2012-11-18 10:52

近日,国际著名杂志《糖尿病学》DIABETOLOGIA在线刊登了英国诺丁汉大学等机构的研究人员的最新研究成果“Peri-conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-b

近日,国际著名杂志《糖尿病学》DIABETOLOGIA在线刊登了英国诺丁汉大学等机构的研究人员的最新研究成果“Peri-conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-based cohort study,”,文章中,研究者报告说,他们研究发现女性患糖尿病易致婴儿先天缺陷。

这项研究显示,女性在患有糖尿病时生育,会导致婴儿出现先天缺陷的风险上升,但如果采取措施控制血糖则可以减少这种风险。

研究人员调查了1996年到2008年间英格兰北部超过40万名孕妇的情况,结果发现,那些在怀孕时患有糖尿病的女性,其婴儿出现先天性心脏病或脊柱裂等缺陷的风险是其他孕妇的4倍。

进一步分析显示,这种风险是与孕妇的血糖含量密切相关的,有些孕妇虽然患有糖尿病,但通过治疗把血糖含量控制在正常范围内,她们的婴儿出现先天缺陷的风险就会少很多。

研究人员露特·贝尔指出,所有患糖尿病的女性如果计划怀孕,最好都先咨询医生,采取措施降低血糖含量。她认为,通过医疗专家在孕前和孕期中的帮助,大部分患有糖尿病的孕妇也可以最终产下健康的宝宝。(生物谷Bioon.com)

Peri-conception hyperglycaemia and nephropathy are associated with risk of congenital anomaly in women with pre-existing diabetes: a population-based cohort study

R. Bell, S. V. Glinianaia, P. W. G. Tennant, R. W. Bilous and J. Rankin

Aims The aim of this study was to quantify the risk of major congenital anomaly, and to assess the influence of peri-conception HbA1c and other clinical and socio-demographic factors on the risk of congenital anomaly occurrence in offspring of women with type 1 and type 2 diabetes diagnosed before pregnancy. Methods This was a population-based cohort study using linked data from registers of congenital anomaly and diabetes in pregnancy. A total of 401,149 singleton pregnancies (1,677 in women with diabetes) between 1996 and 2008 resulting in live birth, fetal death at ≥20 weeks’ gestation or termination of pregnancy for fetal anomaly were included. Results The rate of non-chromosomal major congenital anomaly in women with diabetes was 71.6 per 1,000 pregnancies (95% CI 59.6, 84.9), a relative risk of 3.8 (95% CI 3.2, 4.5) compared with women without diabetes. There was a three- to sixfold increased risk across all common anomaly groups. In a multivariate analysis, peri-conception glycaemic control (adjusted OR [aOR] 1.3 [95% CI 1.2, 1.4] per 1% [11 mmol/mol] linear increase in HbA1c above 6.3% [45 mmol/mol]) and pre-existing nephropathy (aOR 2.5 [95% CI 1.1, 5.3]) were significant independent predictors of congenital anomaly. Associations with gestation at booking (aOR 1.1 [95% CI 1.0, 1.1]) and parity (aOR 1.6 [95% CI 1.0, 2. 5]) were not significant. Unadjusted risk was higher for women from deprived areas or who did not take folate. Type and duration of diabetes, ethnicity, age, BMI, preconception care, smoking and fetal sex were not associated with congenital anomaly risk. Conclusions Peri-conception glycaemia is the most important modifiable risk factor for congenital anomaly in women with diabetes. The association with nephropathy merits further study.

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