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J Urology:减肥可减少糖尿病患者尿失禁

来源:生物谷 2012-02-03 07:57

最近,据一项刊登在《泌尿外科杂志》The Journal of Urology杂志上的研究"Weight Loss Prevents Urinary Incontinence in Women With Type 2 Diabetes: Results From the Look AHEAD Trial"表明:超重的患有糖尿病的妇女可以通过减肥来减少尿失禁的风险。

在这项随机对照研究中,研究人员发现那些控制饮食结构和参加体育运动组别中的超重糖尿病妇女能在短短一年里体重平均减少17磅。在这一年当中,那些没有改变生活方式的糖尿病女性患者有14%的人出现了尿失禁症状,而在那些减肥成功的糖尿病女性患者中,只有10.5%的人有现尿失禁的情况。

该项研究的主要参与人员--加州州立理工大学的首席研究员Suzanne-Phelan博士表示:那些2型糖尿病妇女患者在体重超重以及肥胖后,要积极考虑通过减肥来降低尿失禁发病率。

根据这项研究所得数据显示:一个患有糖尿病并且超重的妇女只要每减两磅,那她出现尿失禁的几率便会下降3%。但另一方面,研究人员发现减肥这种方式对那些已经出现尿失禁情况的糖尿病女性患者是没有帮助的。

同时,Phelan博士强调相关研究人员至今也不能解释,为什么减肥只对预防尿失禁状况的出现有帮助,而对尿失禁的治疗没有作用这一科学问题。Phelan博士猜测:不能解释这一问题的是由于能用来检验减肥对尿失禁症状有无治疗效果的糖尿病女性患者数量太少的缘故。(生物谷 Bioon.com)

Weight Loss Prevents Urinary Incontinence in Women With Type 2 Diabetes: Results From the Look AHEAD Trial

Suzanne Phelanemail address,Alka M. Kanaya,Leslee L. Subak,Patricia E. Hogan,Mark A. Espeland,Rena R. Wing,Kathryn L. Burgio,Vicki DiLillo,Amy A. Gorin,Delia S. West,Jeanette S. Brown,The Look AHEAD Research Group

Purpose

We determined the effect of weight loss on the prevalence, incidence and resolution of weekly or more frequent urinary incontinence in overweight/obese women with type 2 diabetes after 1 year of intervention in the Look AHEAD (Action for Health in Diabetes) trial.

Materials and Methods

Women in this substudy (2,739, mean ± SD age 57.9 ± 6.8 years, body mass index 36.5 ± 6.1 kg/m2) were randomized into an intensive lifestyle weight loss intervention or a diabetes support and education control condition.

Results

At baseline 27% of participants reported urinary incontinence on a validated questionnaire (no significant difference by intensive lifestyle intervention vs diabetes support and education). After 1 year of intervention the intensive lifestyle intervention group in this substudy lost 7.7 ± 7.0 vs 0.7 ± 5.0 kg in the diabetes support and education group. At 1 year fewer women in the intensive lifestyle intervention group reported urinary incontinence (25.3% vs 28.6% in the diabetes support and education group, p = 0.05). Among participants without urinary incontinence at baseline 10.5% of intensive lifestyle intervention and 14.0% of diabetes support and education participants experienced urinary incontinence after 1 year (p = 0.02). There were no significant group differences in the resolution of urinary incontinence (p >0.17). Each kg of weight lost was associated with a 3% reduction in the odds of urinary incontinence developing (p = 0.01), and weight losses of 5% to 10% reduced these odds by 47% (p = 0.002).

Conclusions

Moderate weight loss reduced the incidence but did not improve the resolution rates of urinary incontinence at 1 year among overweight/obese women with type 2 diabetes. Weight loss interventions should be considered for the prevention of urinary incontinence in overweight/obese women with diabetes.

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