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Nat Com:MDSPCs在儿童早衰症上具潜在的治疗价值

来源:生物谷 2012-01-07 22:06

1月3日,国际著名杂志《自然-通讯》Nature Communications在线刊登了美国匹兹堡大学研究人员的最新研究成果“Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model,”,文章中,作者揭示了,在早衰小鼠模型中肌肉衍生干细胞或者祖细胞的功能紊乱会限制小鼠的健康状况和寿命。

肌肉衍生的干细胞/祖细胞(MDSPCs)是从骨骼肌肉中分离出来的细胞,众所周知,肌肉组织是随着年龄增加而慢慢萎缩并且功能下降的,这些细胞并不能被明显区分出来,也不能进行准确定量,文章中,作者运用的MDSPCs是来自野生老鼠和加速老化的老鼠体内的,而且这些细胞运用了特殊的技术固定了下来,通过作者的进一步研究,他们发现来自老年鼠和早衰鼠的MDSPCs在增殖和多项分化能力上存在缺失,进而会影响这些老鼠的生存能力,但是将年轻老鼠腹膜内的MDSPCs,通过移植进入早衰样老鼠体内后,发现这些细胞可以改善它们体内的退化表现以及组织的血管化;当将这些年轻鼠和老鼠共生长的时候,年轻鼠体内的MDSPCs便可以发挥功效,改善老年鼠体内这些细胞的增殖能力以及变异能力。

研究人员Johnny Huard表示,移植的MDSPCs具有全面系统的综合效应,可以在多重器官系统中产生组织的再分化,因此,MDSPCs在延迟性年龄功能下降和儿童早衰症上具有潜在的治疗价值。(生物谷Bioon.com)

(T.Shen编译 如有问题请及时指正)

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Mitra Lavasani,1, 2 Andria R. Robinson,3, 4 Aiping Lu,1, 2 Minjung Song,1, 2 Joseph M. Feduska,1 Bahar Ahani,1 Jeremy S. Tilstra,5 Chelsea H. Feldman,3 Paul D. Robbins,2, 3, 5 Laura J. Niedernhofer3, 5 & Johnny Huard1, 2, 5

With ageing, there is a loss of adult stem cell function. However, there is no direct evidence that this has a causal role in ageing-related decline. We tested this using muscle-derived stem/progenitor cells (MDSPCs) in a murine progeria model. Here we show that MDSPCs from old and progeroid mice are defective in proliferation and multilineage differentiation. Intraperitoneal administration of MDSPCs, isolated from young wild-type mice, to progeroid mice confer significant lifespan and healthspan extension. The transplanted MDSPCs improve degenerative changes and vascularization in tissues where donor cells are not detected, suggesting that their therapeutic effect may be mediated by secreted factor(s). Indeed, young wild-type-MDSPCs rescue proliferation and differentiation defects of aged MDSPCs when co-cultured. These results establish that adult stem/progenitor cell dysfunction contributes to ageing-related degeneration and suggests a therapeutic potential of post-natal stem cells to extend health.

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