新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » PNAS报道 » PNAS:用胚胎细胞培养出功能健全牙齿

PNAS:用胚胎细胞培养出功能健全牙齿

来源:新浪科技 2009-08-04 15:41

日本科学家已经利用从胚胎里获得的细胞,让成年老鼠长出了功能健全的牙齿。他们希望以后利用该技术让人类长出新器官。

该研究成果发表在美国《国家科学院院刊》(PNAS)上,他们在论文中写道:“这项治疗法或许可以重新恢复部分损毁的器官功能。”这些研究人员介绍了他们是如何利用生物工程方法制成牙胚,或称从老鼠胚胎里获得包含特定细胞的“种子”的。稍后这些“种子”被移植到成年老鼠的颚骨里。

移植37天后,研究人员注意到老鼠开始长出新牙,而且它们已经能用这些新牙慢慢吃东西了。他们在回答媒体的问题时写道:“这些生物工程牙齿的釉质和牙质的硬度,跟自然生长的成年老鼠的牙齿一样。”这些新牙还拥有神经元,老鼠在疼痛试验中做出了反应。

该研究由日本东京理科大学科技研究所的崇史香织(Takashi Tsuji)负责领导,该科研组希望以后能利用这项技术培养人类器官。他们在论文中写道:“再生疗法的最终目标是培养出功能健全的生物工程器官,用来取代因疾病、受伤或衰老而受损或失去的器官。”(生物谷Bioon.com)

生物谷推荐原始出处

PNAS August 3, 2009, doi: 10.1073/pnas.0902944106

Fully functional bioengineered tooth replacement as an organ replacement therapy

Etsuko Ikedaa,b,1, Ritsuko Moritaa,c,1, Kazuhisa Nakaoa,c, Kentaro Ishidaa,c, Takashi Nakamuraa,c, Teruko Takano-Yamamotod, Miho Ogawab, Mitsumasa Mizunoa,c,d, Shohei Kasugaie and Takashi Tsujia,b,c,2

Current approaches to the development of regenerative therapies have been influenced by our understanding of embryonic development, stem cell biology, and tissue engineering technology. The ultimate goal of regenerative therapy is to develop fully functioning bioengineered organs which work in cooperation with surrounding tissues to replace organs that were lost or damaged as a result of disease, injury, or aging. Here, we report a successful fully functioning tooth replacement in an adult mouse achieved through the transplantation of bioengineered tooth germ into the alveolar bone in the lost tooth region. We propose this technology as a model for future organ replacement therapies. The bioengineered tooth, which was erupted and occluded, had the correct tooth structure, hardness of mineralized tissues for mastication, and response to noxious stimulations such as mechanical stress and pain in cooperation with other oral and maxillofacial tissues. This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库