新功能、新界面、新体验,扫描即可下载生物谷APP!
首页 » 冠心病 » PLoS Genetics:确认侵袭性牙周炎与冠心病的基因关联

PLoS Genetics:确认侵袭性牙周炎与冠心病的基因关联

来源:新华网 2009-05-26 17:13

据德新社5月25日报道,德国基尔大学的科学家已确认侵袭性牙周炎与冠心病之间存在基因关联。

德新社援引基尔大学临床分子生物学研究所科学家舍费尔在一个学术会议上的讲话说,基尔大学的科学家在研究侵袭性牙周炎患者9号染色体上的基因变异时发现,与这一疾病相关的基因变异体与冠心病患者身上的有关基因变异体是同样的。科学家们由此推断这两种疾病的病因存在相关性。舍费尔认为,牙医们应该认真对待侵袭性牙周炎,力争尽早确诊,尽快治疗。

基尔大学的科学家今年早些时候在《公共科学图书馆·遗传学》(PLoS Genetics)发表学术论文说,过去一年的多项基因研究已发现CDKN2A和CDKN2B两种基因附近的一个基因区是冠心病的一个主要易感基因位点。而基尔大学的最新研究则确认了这一基因区同样与侵袭性牙周炎的患病风险相关。

侵袭性牙周炎发病快,多发于青少年及青春期人群,易造成患者牙齿迅速脱落。冠心病是冠状动脉粥样硬化性心脏病的简称,是造成过早死亡的主要疾病之一。基尔大学的研究论文指出,这两种疾病有相似的致病因素,比如吸烟、糖尿病等。两种疾病也都有慢性炎症症状。(生物谷Bioon.com)

生物谷推荐原始出处:

PLoS Genet 5(2): e1000378. doi:10.1371/journal.pgen.1000378

Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

Arne S. Schaefer1*, Gesa M. Richter1, Birte Groessner-Schreiber2, Barbara Noack3, Michael Nothnagel4, Nour-Eddine El Mokhtari5, Bruno G. Loos6, S?ren Jepsen7, Stefan Schreiber1

1 Institute for Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Kiel, Germany, 2 Department of Operative Dentistry and Periodontology, University Medical Center Schleswig-Holstein, Kiel, Germany, 3 University Medical Center Carl Gustav Carus der Technischen Universit?t Dresden, Zentrum für Zahn-, Mund- und Kieferheilkunde, Poliklinik für Zahnerhaltung, Dresden, Germany, 4 Institute of Medical Informatics and Statistics, University Medical Center Schleswig-Holstein, Kiel, Germany, 5 Clinic of Cardiology, University Medical Center Schleswig-Holstein, Kiel, Germany, 6 Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), VU University Amsterdam, Amsterdam, The Netherlands, 7 Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany

Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD) and periodontitis. Both diseases are associated with similar risk factors and are characterized by a chronic inflammatory process. In a candidate-gene association study, we identify an association of a genetic susceptibility locus shared by both diseases. We confirm the known association of two neighboring linkage disequilibrium regions on human chromosome 9p21.3 with CHD and show the additional strong association of these loci with the risk of aggressive periodontitis. For the lead SNP of the main associated linkage disequilibrium region, rs1333048, the odds ratio of the autosomal-recessive mode of inheritance is 1.99 (95% confidence interval 1.33–2.94; P = 6.9×10?4) for generalized aggressive periodontitis, and 1.72 (1.06–2.76; P = 2.6×10?2) for localized aggressive periodontitis. The two associated linkage disequilibrium regions map to the sequence of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of CDKN2A/CDKN2B. A closely located diabetes-associated variant was independent of the CHD and periodontitis risk haplotypes. Our study demonstrates that CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases.

温馨提示:87%用户都在生物谷APP上阅读,扫描立刻下载! 天天精彩!


相关标签

最新会议 培训班 期刊库