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首页 » JASN:细胞外基质磷酸化糖蛋白(MEPE)抑制磷酸盐转运

JASN:细胞外基质磷酸化糖蛋白(MEPE)抑制磷酸盐转运

来源:医学空间 2008-11-27 10:00

近期发表在《Journal  of  the  American  Society  of  Nephrology》上的一篇文章报道,细胞外基质磷酸化糖蛋白(Matrix  extracellular  phosphoglycoprotein,MEPE)促进尿磷排出的同时,还可以抑制磷酸盐在肠道的的吸收。

细胞外基质磷酸化糖蛋白(Matrix  extracellular  phosphoglycoprotein,MEPE)是调磷因子之一,可以诱发产生高磷酸盐尿,但其是否影响到磷酸盐的吸收,尚不可知。在此,研究人员应用原位肠绊技术,发现短期灌注  MEPE  可以抑制空肠磷酸盐的吸收,但十二指肠吸收不受影响。同时对尿磷酸盐测定显示,MEPE  引起磷酸盐尿与肾近曲小管钠-磷共同转运体水平减低有关。这种短期的效应对血液循环中甲状旁腺素、1,25-二羟维生素D  或成纤维细胞生长因子23无影响。研究结果提示,MEPE  作为调磷因子之一对磷酸盐的吸收和排泄均有影响。(生物谷Bioon.com)

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J Am Soc Nephrol 19: 2313-2320, 2008 doi: 10.1681/ASN.2008030315

Matrix Extracellular Phosphoglycoprotein Inhibits Phosphate Transport

Joanne Marks*, Linda J. Churchill*, Edward S. Debnam* and Robert J. Unwin*,

London Epithelial Group, * Department of Physiology and  Centre for Nephrology, University College London (Royal Free Campus), London, United Kingdom

The role of putative humoral factors, known as phosphatonins, in phosphate homeostasis and the relationship between phosphate handling by the kidney and gastrointestinal tract are incompletely understood. Matrix extracellular phosphoglycoprotein (MEPE), one of several candidate phosphatonins, promotes phosphaturia, but whether it also affects intestinal phosphate absorption is unknown. Here, using the in situ intestinal loop technique, we demonstrated that short-term infusion of MEPE inhibits phosphate absorption in the jejunum but not the duodenum. Simultaneousmeasurement of urinary phosphate excretion suggests that the phosphaturic action of MEPE correlates with a significant reduction in the protein levels of the renal sodium-phosphate co-transporter NaPi-IIa in the proximal convoluted tubules of the outer renal cortex, assessed by Western blotting and immunohistochemistry. This short-term inhibitory effect of MEPE on renal and intestinal phosphate handling occurred without any changes in circulating levels of parathyroid hormone, 1,25-dihydroxyvitamin D3, or fibroblast growth factor 23. Taken together, these findingssuggest that MEPE is a candidate phosphatonin involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract.

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