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PNAS:锻炼可以逆转小鼠大脑的辐射损伤

来源:EurekAlert!中文版 2008-09-03 12:33

科学家报告说,锻炼可以帮助恢复干细胞的生长,而且可以改善大脑被临床剂量的辐射损伤的年轻小鼠的注意缺陷行为。目前,许多接受脑瘤放射性疗法的人类青少年后来出现了可能与注意缺陷有关的学习和记忆问题。这些问题与辐射有关联,后者不但可以杀死癌细胞,也可以伤害海马区的干细胞。

海马区是一个对于工作记忆至关重要的区域。Georg Kuhn及其同事让出生9天的小鼠暴露在相当于人类癌症患者接受的辐射剂量下。让其中一半的小鼠能使用一个转笼。在13周的时候,这些小鼠被放置在了一个开放空间中,同时这组科学家分析它们运动的模式。4周之后,这些小鼠被杀死,对它们的大脑中的新生干细胞和神经元进行了检查。这组科学家发现进行了锻炼的小鼠的大脑含有的干细胞比没进行锻炼的小鼠多大约50%,而且这些干细胞发育成神经元的可能性更高。这组作者提出,锻炼可能在一定程度上逆转儿童患者的大脑辐射损伤。(生物谷Bioon.com)

生物谷推荐原始出处:

PNAS doi:10.1073/pnas.0711128105

Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain

Andrew S. Naylor, Cecilia Bull, Marie K. L. Nilsson, Changlian Zhu, Thomas Bj?rk-Eriksson, Peter S. Eriksson, Klas Blomgren, and H. Georg Kuhn

Cranial radiation therapy is commonly used in the treatment of childhood cancers. It is associated with cognitive impairments tentatively linked to the hippocampus, a neurogenic region of the brain important in memory function and learning. Hippocampal neurogenesis is positively regulated by voluntary exercise, which is also known to improve hippocampal-dependent cognitive functions. In this work, we irradiated the brains of C57/BL6 mice on postnatal day 9 and evaluated both the acute effects of irradiation and the effects of voluntary running on hippocampal neurogenesis and behavior 3 months after irradiation. Voluntary running significantly restored precursor cell and neurogenesis levels after a clinically relevant, moderate dose of irradiation. We also found that irradiation perturbed the structural integration of immature neurons in the hippocampus and that this was reversed by voluntary exercise. Furthermore, irradiation-induced behavior alterations observed in the open-field test were ameliorated. Together, these results clearly demonstrate the usefulness of physical exercise for functional and structural recovery from radiation-induced injury to the juvenile brain, and they suggest that exercise should be evaluated in rehabilitation therapy of childhood cancer survivors.

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