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肌肉干细胞能长期有效治疗尿失禁

来源:生物通 2007-05-25 09:26

    生物谷报道:美国匹兹堡大学医学院和多伦多Sunnybrook健康科学中心的研究人员进行的一项研究显示,通过给女性压力性尿失禁(SUI,stress  urinary  incontinence)患者注射肌肉干细胞来加强她们的括约肌的方法能够长期改善她们的病情。这项研究的结果在美国泌尿科协会年会上公布。

    这项研究对患者进行了一年的跟踪研究,调查结果显示,这种干细胞注射方法很安全,能够改善患者的生活质量并可能有效治疗SUI。

    研究的主要负责人之一,匹兹堡大学的Michael  B.  Chancellor教授表示,这项临床试验的结果很令人激动。研究人员首次证实,能够给SUI患者提供一种长期有效的低侵入性治疗选择。 

     匹兹堡大学之前对SUI动物模型进行的研究证实,将干细胞注射到尿道肌肉中能够增加漏尿点压(leak  point  pressure),从而使肌肉功能得以恢复。这些研究的结果成为了临床试验的基础。

    在这项研究中,研究人员先获得8名女性患者的骨骼肌组织活组织切片,并从这些组织中分离出干细胞,然后进行扩增培养。研究人员给门诊患者注射了这种肌肉干细胞。他们利用三种不同的注射技术给患者注射了相同剂量的干细胞。

    目前,加拿大进行的一项多个研究机构参与的研究和美国的一项相关研究正在进行中,这些研究将使研究人员能够确定出有效治疗SUI的最佳干细胞注射剂量。

英文原文:

Source: University of Pittsburgh Schools of the Health Sciences
Date: May 21, 2007
More on:
Stem Cells, Urology, Women's Health, Healthy Aging, Skin Cancer, Prostate Cancer

Muscle Stem Cells Effectively Treat Urinary Incontinence Long Term

Science Daily — Women with stress urinary incontinence (SUI) treated using muscle-derived stem cell injections to strengthen their sphincter muscles experience long-term improvements in their condition, according to a study led by researchers at the University of Pittsburgh School of Medicine and Sunnybrook Health Sciences Centre in Toronto. The study, which followed patients for more than one year, suggests that the approach is safe, improves patients' quality of life and may be an effective treatment for SUI. 

"This clinical trial is extremely encouraging, given that 13 million people in the United States, most of them women, cope with stress urinary incontinence," said Michael B. Chancellor, M.D., the study's senior author and professor of urology and gynecology at the University of Pittsburgh School of Medicine. "We're demonstrating for the first time that we may be able to offer people with SUI a long-term and minimally invasive treatment option."

"The technique to achieve optimal efficacy is evolving, but we are pleased with what this study has shown," added principal investigator Lesley Carr, M.D., urologist at Sunnybrook Health Sciences Centre and assistant professor at the University of Toronto. "We now have preliminary evidence that stem cells are safe to use and appear to improve female stress urinary incontinence."

Previous studies in animal models of SUI completed at the University of Pittsburgh School of Medicine demonstrated that injecting stem cells into the urethral muscles increases leak point pressure, leading to the restoration of the deficient muscles. The results of these studies formed the basis for the clinical trial.

In the study, Dr. Carr and colleagues took biopsies of skeletal muscle tissue from eight female patients and isolated and expanded the stem cells from the tissue in culture. In an outpatient setting, the patients then received injections of the muscle-derived stem cells into the area surrounding the urethra. Each patient received an equal dose of stem cell injections using three different injection techniques -- a transurethral injection with either an 8-mm or 10-mm needle or a periurethral injection.

Five of the eight women who participated in the study reported improvement in bladder control and quality of life with no serious short- or long-term adverse effects one year after the initial treatment. These improvements were associated with both the 10-mm needle injections and the periurethral injections, which allowed the investigators to deliver the stem cells close to the damaged sphincter muscle. The 8-mm needle was not able to deliver the muscle stem cells deep enough into the tissue to reach the sphincter.

A multi-center study in Canada and a study in the United States are currently underway and will allow researchers to determine the optimal dose of muscle stem cells needed to effectively treat SUI. 

Women with SUI involuntarily leak urine during activities that put pressure on the bladder, such as running, coughing, sneezing or laughing. Stress incontinence is caused by childbirth, menopause or pelvic surgery and is most often diagnosed in women during middle-age.

The findings were presented at the Tissue Engineering and Regenerative Medicine in Urology briefing at the annual meeting of the American Urological Association (AUA) in San Diego, and will be published in Abstract 1331 in the AUA proceedings.

In addition to Drs. Carr and Chancellor, other contributors to the study included Deborah Steele and Shannon Steele, with Sunnybrook Health Sciences Centre; Janet Erickson and Wendy Leng, M.D., with the University of Pittsburgh; and David Wagner, Ryan Pruchnic and Ron Jankowski with Cook MyoSite Inc. The study was funded by Cook MyoSite Inc. of Pittsburgh. Dr. Chancellor serves as a paid consultant to CookMyoSite and maintains a financial interest in the company.

Note: This story has been adapted from a news release issued by University of Pittsburgh Schools of the Health Sciences.

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