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欧洲进行研发可使骨骼再生的聪明材料

来源:华文生技网 2007-04-11 09:22

    欧盟有超过50万人且美国有超过一百万人的骨头结构发生严重缺陷。治疗方式包括移植或植入人造植入物,以缓和损伤,但是制造的材料却影响治疗的结果。

    由INASMET-Tecnalia 带领的欧洲Nanobiocom计划,进行骨骼组织的再生修补的研究。这项计划的目标是获得可使骨头再生,且与自然状态相似的替补材料。

    西班牙巴伦西亚生物力学研究所及 Prognika S.A. Biopharma 等研究机构也参与了这项计划。

    Nanobiocom计划将目标瞄准于研发可作为支撑基质(当作细胞生长的支架)的复合材料,并藉以修补和使骨头组织再生。

    此外,这种材料必须是生物活化性,可以在组织中发挥作用,而且对于生理和生物变化生适当的反应。这种材料也必需是三度空间的,以确保在人体内的生物兼容性。

     (资料来源 : Bio.com)

英文原文:

Intelligent Materials to Regenerate Bone Tissue

03/30/07 -- More than half a million people in the European Union and a million in the United States suffer from disorders in or serious defects of some part of their bone structure. Operations involving grafts or implants, required to mitigate the damage, depend decisively on the materials used.

The European Nanobiocom project, led by INASMET-Tecnalia with the help of others, is working on the regeneration and repair of bone tissue. Seven other bodies, leaders in innovation within this specialism, are also taking part in the project. The goal is to come up with a substitute for bone tissue that can put the bone right and regenerate in such a way that it carries out similar functions as in its natural state. From Spain the Institute of Biomechanics of Valencia and Prog?nika Biopharma S.A. are also participating.

In the case of substantial deterioration of the bone, it may be necessary for the implant to provide both functional and physiological properties of the damaged item. Given this hypothesis, the bone implants have to comply with a series of requisites capable of contributing to a reconstruction of the deteriorated bone tissue in the most efficient and least discomfiting manner, without any serious repercussion. Another exigency involves the carrying out of the mechanical functions of the damaged bone while the desired regeneration takes place.

The solutions have to be capable, moreover, of remedying particularly serious damage, such as those due to congenital deficiencies, degenerative illnesses, cancerous disorders and other damage caused by accidents. The implants required for this type of solutions are more complex and sophisticated than the small implants known to date.

The Nanobiocom project aims at developing a support matrix (scaffold) of a compound material that is ?intelligent?, proactive, and capable of repairing and regenerating bone tissue. To this end, it has to be bioactive, capable of acting on the tissue-generating system and its corresponding genes, as well as respond appropriately to the physiological and biological changes, both internal and external, of that system.

Also necessary are size and shape characteristics, as well as mechanical functions appropriate to healthy bones.

The specific tasks of the project focus on putting the finishing touches to the intelligent material, based on nanoparticles and of a biodegradable nature. Also to be developed is the cell culture in three dimensions, as well as ensuring the biocompatibility of the material.

Source: Basque Research

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